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Beta-3 receptors are concentrated in adipose tissue and play a primary role in thermogenesis and lipolysis

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Studies show it promotes angiogenesis (new blood vessel growth), stimulates tissue regeneration in muscle, tendon, ligament, and bone, reduces inflammation, and supports gut health increasing delivery of growth factors to injury sites and reducing inflammatory cytokines

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Stimulation with exogenous TNF- per se downregulates VDR/PGC-1/GLUT-4 in myotubes (Fig